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Simple demographic, laboratory and chest radiograph variables can identify COVID-19 patients with pulmonary thromboembolism: a retrospective multicentre United Kingdom study

Published November 2023 in the British Journal of Radiology which can be read here.

 

Aims:

To (1) identify discriminatory demographic, laboratory and initial CXR findings; (2) explore correlation between D-dimer and radiographic severity scores; and (3) assess accuracy of published D-dimer thresholds to identify pulmonary thromboembolism (PTE) in COVID-19 patients.

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Our main findings:

  • At admission, COVID patients that were male, had a high neutrophil count, abnormal CXR and a greater CXR zonal severity score were more likely to have a PE

  • Only the neutrophil count at the time of peak D-dimer was a significant predictor of PE

  • The higher the CXR zonal severity score, the higher the D-dimer values

  • None of the D-dimer thresholds were reproducible in our population (ie we had a much lower sensitivy for cut off values used in similar studies across the world). I personally find these results quite interesting [see Table 3(b)] as some UK hospitals use d-dimer cut offs for CTPA requests, but our study shows that you shouldn't really use these in COVID patients as both COVID and PE can put up the D-dimer levels. 

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Thank you to everyone who took part in the study! 

Simple demographic, laboratory and chest radiograph.png

We at RADIANT value diversity and inclusivity and welcome all members irrespective of age, gender, disability, sexual orientation, ethnic background, religion or belief.

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Created with Wix.com by Nathan Chan

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